METABOLIC EFFECTS OF ANABOLIC STEROIDS* Professor V. WYNN

نویسنده

  • Alexander Simpson
چکیده

Everyone is familiar with the rapid weight gain which occurs in both boys and girls with the onset of puberty. At this time there is also a spurt in the rate of growth. These effects are brought about by increased secretion of the sex steroids, testosterone in males and oestrogen and progesteronein females, which occurs at puberty and is maintained thereafter. The physical difference between men and women is also fairly well recognised by most people. The more muscular male owes this mainly to testosterone. The female curves, mainly due to adipose tissue, are an oestrogen effect. The protein anabolic effect of testosterone is well recognised and can be exploited therapeutically. The term 'anabolic' implies that the substance under consideration is being synthesized and stored. In the context of today's discussion the term 'anabolic steroid' refers to compounds which increase the production of protein in the body. Testosterone is the most powerful of the anabolic steroids in humans and as already mentioned, is responsible for the greater muscle mass of men compared to women. Women who are given testosterone develop masculine characteristics, namely increased muscle mass, beard growth, greasiness of the skin, deepening of the voice, loss of hair from the scalp and other changes which need not be referred to here. These latter effects are referred to as the virilising action of testosterone. In the adult male who is secreting normal amounts of testosterone, additional amounts given by injection do not produce virilising effects, but testosterone may be anabolic if enough is given and the individual may gain weight and increase his muscle mass. Women are more sensitive to the effects of testosterone and it cannot be given for any significant length of time without producing both anabolic and virilising effects.

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تاریخ انتشار 2005